Prime Immunity Bundle – 60 Day Supply

Description

Prime Immunity

Prime Immunity contains 250mg of beta-glucan, which has been the subject of more than 800 scientific studies and is recognized for its support of the immune system. Our purified beta-glucans are derived from the yeast Saccharomyces cerevisiae, the most effective source. Among its many immune-boosting effects, it has been shown to stimulate neutrophil (a type of white blood cell) activity, improve antioxidant function, decrease tissue-damaging cytokine inflammation, and improve microbial balance. It is recommended to use regularly to improve resilience to infections, as well as during times of acute illness to accelerate recovery.

Prime Immunity Ingredients

Whole Glucan Particle (providing beta-glucan naturally derived from Saccharomyces cerevisiae), Dicalcium phosphate anhydrous, HPMC (capsule), stearic acid, magnesium stearate, silica, and medium-chain triglyceride oil.

Prime Immunity Directions

• For ongoing immune support: Take one capsule daily, first thing in the morning or last thing at night (before or well after a meal), with a full 8 oz glass of water. For fast-acting immune support:
• Take up to two capsules per day, as above; or use as directed by your healthcare practitioner.*
• Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if the tamper seal is damaged.

Prime Immunity Does NOT Contain

Wheat, gluten, corn, yeast protein, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Sources:

1. Tian J, Ma J, Wang S, et al. Increased expression of mGITRL on D2SC/1 cells by particulate β-glucan impairs the suppressive effect of CD4(+)CD25(+) regulatory T cells and enhances the effector T cell proliferation. Cell Immunol. 2011 May 10;270(2):183-7. [PMID: 21636079]
2. Feldman S, Schwartz HI, Kalman DS, et al. Randomized phase II clinical trials of Wellmune WGP® for immune support during cold and flu season. J Appl Res. 2009 March-June;9(1&2):30-42. Accessed September 9, 2011.
3. Driscoll M, Hansen R, Ding C, et al. Therapeutic potential of various beta-glucan sources in conjunction with anti-tumor monoclonal antibody in cancer therapy. Cancer Biol Ther. 2009 Feb;8(3):218-25. [PMID: 19106638]
4. Liang, J., D. et al. Enhanced clearance of a multiple antibiotic-resistant Staphylococcus aureus in rats treated with PGG-glucan is associated with increased leukocyte counts and increased neutrophil oxidative burst activity. Int J Immunopharmacol. 1998 Nov;20(11):595-614. [PMID: 9848393]
5. Vetvicka V. Glucan-immunostimulant, adjuvant, potential drug. World J Clin Oncol. 2011 Feb 10;2(2):115-9. [PMID: 21603320]
6. Vetvicka V, Terayama K, Mandeville R, et al. Pilot study: orally-administered yeast ß1,3-glucan prophylactically protects against anthrax infection and cancer in mice. JANA. 2002;5(2):5-9. Reprint. Accessed August 21.
7. Natural Standard Database. Accessed July 23, 2011.
8. Yan J, Allendorf DJ, Brandley B. Yeast whole glucan particle (WGP) beta-glucan in conjunction with antitumour monoclonal antibodies to treat cancer. Expert Opin. Biol Ther. 2005 May;5(5):691-702. [PMID: 15934844]
9. Qi C, Cai Y, Gunn L, et al. Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived ß-glucans. Blood. 2011 Jun 23;117(25):6825-36. [PMID: 21531981]
10. Pelizon AC, Kaneno R, Soares AM, et al. Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae. Physiol Res. 2005;54(5):557-64. [PMID: 16238470]
11. Tsikitis V, Albina J, Reichner J. Beta-glucan affects leukocyte navigation in a complex chemotactic ingredient. Surgery. 2004 Aug;136(2):384-9. [PMID: 15300205]
12. Senoglu N, Yuzbasioglu MF, Aral M, et al. Protective effects of N-acetylcysteine and beta-glucan pretreatment on oxidative stress in cecal ligation and puncture model of sepsis. J Invest Surg. 2008 Sep-Oct;21(5):237-43. [PMID: 19160131]
13. Turnbull, JL, Patchen ML, Scadden DT. The polysaccharide, PGGglucan, enhances human myelopoiesis by direct action independent of and additive to early-acting cytokines. Acta Haematol. 1999;102(2):66-71. [PMID: 10529508]
14. Kournikakis B, Mandeville R, Brousseau P, et al. Anthrax-protective effects of yeast beta 1,3 glucans Med Gen Med. 2003 Mar 21;5(1):1. [PMID:12827062]

Prime Zinc

Zinc is a fully reacted, proprietary TRAACS® amino acid chelate formulated for enhanced absorption. As an essential mineral, zinc serves catalytic, structural, and regulatory functions in the body. Zinc ultimately supports immune and neurological function, growth, taste acuity, nutrient metabolism, and reproductive health.*

Deficiency is common and can result from poor dietary intake, poor absorption, excessive losses through urine, stool, perspiration, or lactation, taking certain drugs, certain herbs, poor kidney function, excessive alcohol intake, and drinking mostly “soft” water can contribute to magnesium depletion as well. Albion’s TRAACS® magnesium lysinate glycinate is an excellent delivery system for magnesium, is resistant to competitive minerals, and does not weaken the action of vitamins.

Prime Zinc Ingredients

Zinc (as TRAACS® zinc bisglycinate chelate) 20 mg 182%. Other Ingredients: Microcrystalline cellulose, HPMC (capsule), stearic acid,
magnesium stearate, and silica.

Prime Zinc Directions

• Take 1 capsule daily, or as suggested by your healthcare provider
• Consult your healthcare practitioner. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if the tamper seal is damaged.

Prime Zinc Does NOT Contain

Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Sources:

Zinc Glycinate is a fully reacted, proprietary TRAACS® amino acid chelate formulated for enhanced absorption. It’s estimated that at least 12% of the American population is deficient in zinc due to poor absorption and dietary intake. As an essential mineral, zinc serves catalytic, structural, and regulatory functions in the body. Zinc supports immune and neurological function, growth, taste acuity, nutrient metabolism, and reproductive health.

Resources:

• K. Ryan Wessells and Kenneth H. Brown. Estimating the Global Prevalence of Zinc Deficiency: Results Based on Zinc Availability in National Food Supplies and the Prevalence of Stunting. PLoS One. 2012; 7(11): e50568. PMID: 23209782
• Ananda S Prasad. Zinc in Human Health: Effect of Zinc on Immune Cells. Mol Med. 2008 May-Jun; 14(5-6): 353–357. PMID: 18385818
• Zinc helps against infection by tapping brakes in immune response. February 7, 2013. Ohio State University.
• https://www.sciencedaily.com/releases/2013/02/130207131344.htm
• Shannon D. Gower-Winter1 and Cathy W. Levenson1,2. Zinc in the central nervous system: From molecules to behavior. Biofactors. Author manuscript; available in PMC 2013 Aug 30. PMID: 22473811
• Tyszka-Czochara M et al. The role of zinc in the pathogenesis and treatment of central nervous system (CNS) diseases. Implications of zinc homeostasis for proper CNS function. Acta Pol Pharm. 2014 May-Jun;71(3):369-77. PMID: 25265815
• Favier AE1. The role of zinc in reproduction. Hormonal mechanisms. Biol Trace Elem Res. 1992 Jan-Mar;32:363-82. PMID: 1375078

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Prime C

Prime C is a highly potent vitamin C formula containing Bioperine, a black pepper extract that promotes the absorption and bioavailability of vitamin C. Vitamin C boosts immune function by increasing the production and function of various white blood cells, the cells that fight infection in our bodies. Vitamin C also provides potent antioxidant activity and is a necessary component for the production of collagen (found in ligaments, tendons, skin, hair, bones, etc).

Prime C Ingredients

Vitamin C (as calcium ascorbate, magnesium ascorbate, and potassium ascorbate)

Prime C Directions

Take one capsule twice daily, or as directed by your healthcare practitioner. Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if the tamper seal is damaged.

Does NOT Contain

Wheat, gluten, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Sources:

1. Prinz W, Bortz R, Bregin B, Hersch M. The effect of ascorbic acid supplementation on some parameters of the human immunological defence system. Int J Vitam Nutr Res. 1977;47(3):248-257. (PubMed)
2. Vallance S. Relationships between ascorbic acid and serum proteins of the immune system. Br Med J. 1977;2(6084):437-438. (PubMed)
3. Kennes B, Dumont I, Brohee D, Hubert C, Neve P. Effect of vitamin C supplements on cell-mediated immunity in old people. Gerontology. 1983;29(5):305-310. (PubMed)
4. Panush RS, Delafuente JC, Katz P, Johnson J. Modulation of certain immunologic responses by vitamin C. III. Potentiation of in vitro and in vivo lymphocyte responses. Int J Vitam Nutr Res Suppl. 1982;23:35-47. (PubMed)
5. Jariwalla RJ, Harakeh S. Antiviral and immunomodulatory activities of ascorbic acid. In: Harris JR, ed. Subcellular Biochemistry. Ascorbic Acid: Biochemistry and Biomedical Cell Biology. New York: Plenum Press; 1996:215-231.
6. Anderson R, Oosthuizen R, Maritz R, Theron A, Van Rensburg AJ. The effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers. Am J Clin Nutr. 1980;33(1):71-76. (PubMed)
7. Levy R, Shriker O, Porath A, Riesenberg K, Schlaeffer F. Vitamin C for the treatment of recurrent furunculosis in patients with imparied neutrophil functions. J Infect Dis. 1996;173(6):1502-1505. (PubMed)
8. Anderson R. The immunostimulatory, antiinflammatory and anti-allergic properties of ascorbate. Adv Nutr Res. 1984;6:19-45. (PubMed)
9. Huijskens MJ, Walczak M, Koller N, et al. Technical advance: ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells. J Leukoc Biol. 2014;96(6):1165-1175. (PubMed)
10. Schwager J, Bompard A, Weber P, Raederstorff D. Ascorbic acid modulates cell migration in differentiated HL-60 cells and peripheral blood leukocytes. Mol Nutr Food Res. 2015;59(8):1513-1523. (PubMed)
11. Bozonet SM, Carr AC, Pullar JM, Vissers MC. Enhanced human neutrophil vitamin C status, chemotaxis and oxidant generation following dietary supplementation with vitamin C-rich SunGold kiwifruit. Nutrients. 2015;7(4):2574-2588. (PubMed)
12. NIH Office of Dietary Supplements. Dietary Supplement Fact Sheet: Vitamin C. Accessed September 3, 2012.
13. Schlueter AK, Johnston CS. Vitamin C: overview and update. Journal of Evidence-Based Complementary & Alternative Medicine (JEBCAM). 2011; 16(1) 49-57. Accessed August 23, 2012.
14. Linus Pauling Institute. Vitamin C. Updated November 2009. Accessed August 15, 2012.
15. Johnston CS. The antihistamine action of ascorbic acid. Subcell Biochem. 1996;25:189-213. [PMID: 8821975]
16. Strohle A, Wolters M, Hahn A. Micronutrients at the interface between inflammation and infection—ascorbic acid and calciferol: part 1, general overview with a focus on ascorbic acid. Inflamm Allergy Drug Targets. 2011 Feb;10(1):54-63. [PMID: 21184650]
17. MacKay D, Miller AL. Nutritional support for wound healing. Altern Med Rev. 2003 Nov;8(4):359-77. [PMID: 14653765]
18. Lanman TH, Ingalls TH. Vitamin C deficiency and wound healing: An experimental and clinical study. Ann Surg. 1937 Apr;105(4):616-25. [PMID: 17856964]
19. Jacob RA, Sotoudeh G. Vitamin C function and status in chronic disease. Nutr Clin Care. 2002 Mar-Apr;5(2):66-74. [PMID: 12134712]
20. Li Y, Schellhorn HE. New developments and novel therapeutic perspectives for vitamin C. J Nutr. 2007 Oct;137(10):2171-84. [PMID: 17884994]
21. Wintergerst ES, Maggini S, Hornig DH. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab. 2006;50(2):85-94. [PMID: 16373990]
22. Douglas RM, Hemilä H, Chalker E, et al. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD000980. [PMID: 17636648]
23. Pauling L. Evolution and the need for ascorbic acid. Proc Natl Acad Sci USA. 1970 Dec;67(4):1643-8. [PMID: 5275366]
24. BioPerine®. About BioPerine®. Accessed September 4, 2012.

Prime D + K 60 Count

By some estimates, one billion people worldwide have vitamin D deficiency or insufficiency, a vitamin whose actions are more like a hormone and involved in thousands of critical reactions in the body. Although vitamin D is produced by the skin when in contact with sunlight, many factors prevent this from happening, like pollution and smog, clothing, sunscreen, darker shade of skin, or winter season.

Vitamin D plays an important role in the innate and adaptive immune system, and has been shown to have antiviral activity. Vitamin D is needed for proper absorption of calcium from the digestive tract, and researchers suggest that vitamin D supplementation may decrease bone turnover and increase bone mineral density.

There is extensive research supporting the use of Vitamin K supplementation on decreasing arterial calcium deposits. Consuming the combination of Vitamin D with K promotes the absorption of dietary calcium, while ensuring the calcium is deposited into your bones, and not your arteries.

Prime D + K 60 Count Ingredients

Vitamin D3 (cholecalciferol) 125 mcg (5000 IU) 625%, Vitamin K2 (as menaquinone-7) 90 mcg 75%, HPMC (capsule), microcrystalline cellulose, ascorbyl palmitate, and silica.

Prime D + K 60 Count Directions

Take 1 daily, or as suggested by your healthcare provider. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Consider total vitamin K intake (food + supplements) if you are taking blood-thinning medication. Do not use if the tamper seal is damaged.

Prime D + K 60 Count Does NOT Contain

Wheat, gluten, yeast, soy protein, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Prime D + K 60 Count Discussion

Naturally occurring vitamin K is found as either K1 (phylloquinone), which is derived from food sources such green leafy vegetables, or K2 (menaquinones). Menaquinones are designated as MK-n, where n denotes the length of the molecule’s aliphatic side chain. Menaquinones are synthesized by bacteria and can be obtained from animal-based and fermented foods. Structural differences between K1 and K2 impact their bioavailability and bioactivity. Furthermore, among menaquinones, menaquinone-7 (MK-7), with its longer side chain, is very hydrophobic. Compared to K1, MK-7’s physiochemical properties make it highly transportable by plasma lipoproteins, increase its extrahepatic (bones, arteries, etc.) availability, and produce its long half-life.[1-3]

Absorption of K1 from food can be limited due to its membrane-bound nature and the individual consumer’s digestive and absorptive variability. Moreover, adequate consumption of foods high in K2 can be challenging. Therefore, dietary supplementation is an important option. In addition, research suggests that higher levels of menaquinones are needed than were previously thought. Supplementary vitamin K can be found in three forms: synthetic K1; MK-4, which is structurally similar to K1; and natural, long-chain MK-7. PrimeHealth provides MK-7 as Vitamk7TM, a naturally derived and solvent-free vitamin K2 that has been obtained through a patent-granted biofermentation process of Bacillus subtilis natto cultures.*

MK-7 Bioavailability Increases Extrahepatic Tissue Utilization

Schurgers et al conducted human studies to compare the in vivo properties of orally administered K1 and MK-7. The results supported better bioavailability and utilization of MK-7. Expressed as AUC96, MK-7 demonstrated a six-fold better half-life, a seven- to eight-fold higher dose- response level, and a three times higher carboxylated to uncarboxylated osteocalcin ratio (cOC:ucOC†). Furthermore, on a molar basis, MK-7 is a three-to-four times more potent antidote for oral anticoagulation than is K1. Researchers note that, aside from sensitive individuals, “MK-7 supplements containing more than 50 mcg/d may interfere with oral anticoagulant treatment, whereas doses of at least 50 mcg are not likely to affect the INR value in a relevant way.”[2] Nonetheless, practitioners should closely monitor patients taking anticoagulants.*

While studies on the absorption and bioavailability of MK-4 at nutritional levels (i.e., doses of 500 mcg/d or lower) suggest less efficacy compared to longer-chain menaquinones at similar doses,[4] this remains subject to debate. It is possible that rapid uptake of MK-4 could account for its observed lack of detection in serum after oral administration,[5] but more studies are needed for clarification.*

Bone Benefits

Among the dietary factors critical to bone health, vitamin K has emerged as a key player. Vitamin K is believed to be necessary for bone mineralization. Through carboxylation, vitamin K activates osteocalcin, the protein needed to bind calcium to the mineral matrix in bone.[6] Several studies have demonstrated the efficacy of MK-7 (e.g., doses of 45-90 mcg/d) to increase osteocalcin carboxylation and to increase the cOC:ucOC ratio. A high cOC:ucOC ratio is associated with bone health.[1,2,4] A recent in vitro study also showed an osteogenic effect of MK-7 administration on human mesenchymal cell differentiation.[6] In addition, the vitamin may protect bone integrity by reducing the synthesis of prostaglandin E2 or interleukin-6 by osteoclasts.[7] Animal and human studies have demonstrated a significant beneficial effect of MK-7 supplementation on bone health.[8-10] Vitamin K and vitamin D share some similar characteristics and are believed to act synergistically.*[11]

Cardiovascular and Other Health Benefits

Vitamin K benefits cardiovascular health by participating in the carboxylation of matrix GLA protein (MGP), a protein regarded to be the most potent inhibitor of arterial calcification. Researchers have demonstrated that supplementation with vitamin K reduces arterial calcium deposits[1,3,12] and that long-term intake of long-chain menaquinones is inversely correlated with calcium accumulation in arteries.*[5]

Vitamin K has specific receptor binding sites that allow it to regulate gene activity.[13] Besides its gene-mediating effects upon critical proteins, the vitamin can also bind with the steroid and xenobiotic receptors and influence their expression.[14] In addition, vitamin K also demonstrates antioxidant activity[15]; reduces levels of certain markers, such as acute phase reactants (e.g., C-reactive protein)[16]; and participates in the induction of apoptosis.*[17]

Vitamin D (as D3)

Although vitamin D3 (cholecalciferol) is made in the skin when 7-dehydrocholesterol reacts with sunlight, many things affect the degree to which this biosynthesis occurs, including time of day, seasons, location, smog/pollution, clothing, shade of skin (darker skin requires more sun), and sunscreen use. Low-cholesterol diets and certain cholesterol therapies can also affect vitamin D formation. By some estimates, one billion people worldwide have vitamin D deficiency or insufficiency.[18] The body needs vitamin D to absorb calcium, and the importance of vitamin D

Sources:

1. Tsiaras WG, Weinstock MA. Factors influencing vitamin d status. Acta Derm Venereol. 2011 Mar;91(2):115-24. [PMID: 21384086]
2. Lips P, van Schoor NM. The effect of vitamin D on bone and osteoporosis. Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):585-91. [PMID: 21872800]
3. Brugè F, Bacchetti T, Principi F, et al. Olive oil supplemented with menaquinone-7 significantly affects osteocalcin carboxylation. Br J Nutr. 2011 Oct;106(7):1058-62. [PMID: 21736837]
4. Beulens JW, Bots ML, Atsma F, et al. High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis. 2009 Apr;203(2):489-93. [PMID: 18722618]
5. Schurgers LJ, Vermeer C. Differential lipoprotein transport pathways of K-vitamins in healthy subjects. Biochim Biophys Acta. 2002 Feb 15;1570(1):27- 32. [PMID: 11960685]
6. Geleijnse JM, Vermeer C, Grobbee DE, et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004 Nov;134(11):3100-05. [PMID: 15514282]
7. Teymoori-Rad M, Shokri F, Salimi V, Marashi SM. The interplay between vitamin D and viral infections. Rev Med Virol. 2019 Mar;29(2):e2032. doi: 10.1002/rmv.2032. Epub 2019 Jan 6. [PMID: 30614127]
8. Cynthia Aranow, MD. Vitamin D and the Immune System. J Investig Med. 2011 Aug; 59(6): 881–886. [PMID: 21527855]