What Is NAD+?
Dubbed the “miracle molecule” by Harvard researchers, NAD+ (nicotinamide adenine dinucleotide) is an essential cofactor in various cellular processes.
Research suggests NAD+ therapy may support:
- Heart health (including blood pressure and risk factors for heart disease)
- Proper cognitive function, such as preventing brain fog and protecting against the development of certain neurodegenerative diseases
- Skeletal muscle function
- Healthy metabolism
- Sleep cycles
- Longer lifespan
- Strength and physical performance
- The prevention of some age-related diseases
NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme in your body’s fundamental biological processes, such as metabolism, sirtuin protein activity, and energy creation (ATP) in the mitochondria. There are almost 300 enzymes dependent on NAD.
A NAD drip is when NAD+ is intravenously (IV) administered into your system, bypassing your digestive tract and supporting cellular function, neurotransmitter availability, and many other vital processes — even addiction recovery.
Common Causes of Low NAD Levels:
- Viral illness
- Alcohol use
- SSRI antidepressant use
- Autoimmune disease
- Sleep deprivation
- Sun exposure
Symptoms of Low NAD Levels:
- Lower metabolism
- Low energy/exercise stamina
- Brain fog, altered brain function
- Chronic fatigue syndrome
- Higher risk of inflammatory conditions
- More DNA damage
5 Ways to Increase NAD+ Levels:
- IV therapy
- Regular exercise
- Diet rich in NAD precursors
- NAD precursor supplements
- Avoiding DNA damage, such as from sun exposure
NAD Injections vs. NAD+ IV Infusions
- NAD Injection: Intramuscular injections involve a needle going straight into a muscle to deliver the liquid solution.
- NAD+ IV Infusion: During an IV infusion, a catheter is inserted into the vein to deliver a larger volume of liquid containing a larger dose of NAD+.
NAD+ infusions (also known as “drips”) and injections are only available with a prescription due to new FDA regulations.
Before you can schedule a NAD+ IV therapy appointment, one of our physicians will assess your condition and prescribe this therapy if appropriate.
NAD IV Drip Pricing:
Most NAD therapy costs $299-$1,000, but at PrimeHealth Denver, we offer individual NAD IV drip sessions starting at $250.
Individual NAD+ IVs:
- 250mg: $250 ($25 off for members)
- 500mg: $450 ($50 off for members)
- 750mg: $600 ($75 off for members)
- 1000mg: $750 ($100 off for members)
- 3x 250mg: $675 ($50 off for members)
- 3x 500mg: $1,200 ($100 off for members)
- 3x 750mg: $1,650 ($150 off for members)
- 3x 1000mg: $2,050 ($250 off for members)
- 100mg: $85 ($10 off for members)
To get started, book a free consult to connect with a provider.
What to Expect During Your Appointment
When you come to PrimeHealth’s integrative clinic in Denver, CO, for a NAD therapy appointment, expect a team member to escort you to our beautiful treatment room. There, you can get comfortable, watch your favorite show, or just relax on our lounge chairs.
NAD+ treatments may be accompanied by various uncomfortable sensations like flushing, shortness of breath, or nausea. The higher the dose, the more uncomfortable the sensations can be, and therefore, the slower you will want to have the IV infusion delivered.
Our healthcare experts are there to support you and make you as comfortable as possible during the process.
Common side effects (headache, shortness of breath, heavy sensation, nausea) typically occur during IV therapy. Side effects tend to resolve when the IV is either slowed down or stopped
What should you wear? Please wear comfortable clothing to your IV therapy session. Wear a top that is short-sleeved or a shirt whose sleeves can easily be rolled up. Tight clothes are not recommended.
People generally feel back to baseline or can experience immediate increases in energy levels following a NAD+ infusion. You are permitted to drive after your session.
Evidence-Based Benefits of NAD IV Therapy
NAD IV therapy may have the following benefits, supported by peer-reviewed research:
- Anti-aging (2020 study)
- Metabolism (2021 scientific review)
- Mitochondrial function (2021 review)
- Heart health (2023 clinical trial)
- Mental health (2022 animal study)
- Anti-inflammation (2022 systematic review)
- Brain health (2021 randomized controlled trial)
- Cravings, withdrawal symptoms (2022 study)
- Long COVID recovery (2022 scientific review)
Reversing aging and increasing lifespan are the most popular reasons that people like you use NAD oral supplements or seek out intravenous administration of NAD+.
One of the advantages of IV therapy over dietary changes or supplements is that IV bypasses the digestive system, where NAD may be broken down. NAD+ IV therapy makes the NAD+ more bioavailable so your body can reset its cellular health.
What are the side effects of NAD+ IV therapy or injections? Generally, there may be some side effects of NAD+ IV drip therapy, such as:
- Chest pressure
- Shortness of breath
- Heaviness sensation
- Redness or tenderness at injection site
In most cases, when the IV infusion is stopped or slowed down, these side effects will subside.
Yes, PrimeHealth sees many patients from outside Denver and outside Colorado, but only in-person. If you come to our Denver clinic in person, you may be prescribed a NAD intramuscular injection or IV infusion after meeting with a provider.
Yes! Most of our patients want either 3-5 sessions in a short period of time or periodic sessions every year. You can talk with our healthcare experts about an IV schedule that works for your unique situation.
Usually, yes! You may customize IV ingredients in your drip therapy sessions. Discuss the best combination of vitamins, minerals, or supplements with our IV health experts.
NAD IV therapy is not FDA-approved to treat any health condition. NAD as a medicine has not gone through phase 3 clinical trials. It is intended as an experimental supplement to your body’s natural levels of NAD.
Functional doctors administer NAD IV therapy to help boost your NAD levels, which may be low due to older age, various illnesses, or frequent sun exposure.
Boosting NAD levels may support:
- metabolic function
- muscle function
- cognitive function
- athletic performance
- DNA repair
- slowing of the aging process
More and more people are turning to NAD+ IV for general wellness.
NAD infusions work for some people’s well-being, especially individuals with low NAD+ levels. Like all treatments, NAD therapy may not work for everyone.
If you have low NAD+ levels (due to older age, autoimmunity, viral illness, etc.), NAD IV therapy has been shown to significantly replenish NAD+ levels in your body. Some patients notice an effect immediately after IV treatment, and they often last a couple of weeks to a month.
Replenishing NAD+ levels may increase energy levels, reduce blood pressure, restore healthy circadian rhythm, improve mental clarity, and protect against neurodegenerative diseases such as Parkinson’s and Alzheimer’s.
Almost all insurance plans will not cover NAD IV therapy.
We offer multiple convenient ways to pay for IV therapy: cash, check, debit, credit, health savings account (HSA), and flexible spending account (FSA).
NADH is the reduced form of active NAD+ — as in, after NAD+ gets used by the body, it turns into the inactive NADH.
NAD+ is able to transfer electrons to assist with biological processes.