Top 11 Supplements for Anxiety: Natural Remedies to Ease Your Mind

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Dietary supplements like ashwagandha, valerian root, and L-theanine can naturally ease your anxiety. There are also lifestyle changes, dietary changes, and medicines that could help.

Anxiety is a feeling of fear, dread, or unease. Anxiety disorders are when certain events or stimuli trigger anxiety, restlessness, panic, and other symptoms.

Recurring anxiety may result in mental health or physical health problems, such as insomnia, constant drowsiness, depression, high blood pressure, heart disease, and damaged brain function.

The best supplements for anxiety often reduce stress levels, induce calm, and regulate your nervous system at the chemical level. Each supplement is different, but many positively impact your overall mental health, not just anxiety.

Talk to your provider before starting or stopping any treatments, even over-the-counter herbal supplements.

Looking for a healthcare provider who’s not afraid to recommend evidence-based natural remedies? Visit us at PrimeHealth in Denver, CO.

1. Magnesium

Known for its calming effect on the nervous system, magnesium is a great anxiety supplement for your immune system and mental health.

Recent research confirms high doses of magnesium supplementation may reduce depression and symptoms of anxiety. This 2021 study measured whether magnesium and B vitamins could help with anxiety. Researchers found that magnesium achieved this benefit on its own.

2. Omega-3 Fatty Acids

Omega-3 fatty acids, especially EPA and DHA, have a long list of health benefits, including relieving anxiety. Found in fish oil and flaxseed oil, omega-3s have been linked to reducing anxiety symptoms in multiple studies.

3. L-Theanine

This amino acid is naturally found in green tea and mushrooms. When extracted, L-theanine supplements may reduce stress-related symptoms, including anxiety and depression.

4. Vitamin D

Vitamin D is a naturally occurring hormone in our bodies. Studies suggest a correlation between low Vitamin D levels and increased anxiety.

Read more: Vitamins For Stress

Vitamin D supplementation not only supports a healthy immune system, but it also exhibits antidepressant and anxiolytic (anti-anxiety) properties.

5. Ashwagandha

The adaptogenic herb ashwagandha helps lower cortisol levels (stress hormone) and calm anxiety levels. Years of research support the anti-anxiety effects of ashwagandha.

Studying all adaptogens can be imprecise, and human clinical trials are still coming in, but most adaptogens may also help with “chronic fatigue, cognitive impairment, and immune protection.”


Gamma-aminobutyric acid (GABA) is your body’s chief inhibitory neurotransmitter. In simple terms, it naturally calms down your nervous system by reducing the excitability of neurons.

GABA supplements support a healthy nervous system and play a significant role in reducing feelings of anxiety and stress. GABA is often associated with promoting relaxation and reducing stress.

7. Valerian Root

Also known as Valeriana officinalis, this ancient Chinese herb is known for its calming effects, often used to improve sleep.

Recent studies reveal that valerian root supplements improve anxiety and depression symptoms. You can find this supplement in capsule form or already infused in tea bags.

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8. Passionflower

The passionflower (Passiflora incarnata) is a rapid-growing vine found in the New World. Also called maypop or wild apricot, passionflower has been used as a remedy for burns, diarrhea, hemorrhoids, and menstrual pain.

According to this 2020 study, passionflower has anxiety-reducing properties, especially among patients with severe anxiety.

I frequently recommend Pique tea to my patients. Try their chamomile, passionflower, or any other tea varieties — just use this link for an extra 10% off!

9. Chamomile

Commonly consumed as a tea, chamomile refers to several similar daisy-like plants. It’s known for its soothing and calming effects. Most often, chamomile is made from Matricaria chamomilla, but some formulations use Chamaemelum nobile.

Researchers found that chamomile is safe and effective in reducing symptoms of generalized anxiety disorder.

10. Cannabidiol

Cannabidiol (CBD) is a cannabis extract that is legal in 47 states. Among its many health benefits, CBD has exhibited anti-anxiety properties in animal studies and human studies, without any reported side effects in many studies.

Future research would benefit from studying CBD’s benefits on female patients, as most research has thus far studied males.

Read more: How Microdosing Can Help You

Get 15% off your first order of Ned CBD with code PRIME.

11. Rhodiola Rosea

Rhodiola rosea may help combat stress and promote a sense of calm. A 2022 scientific review says that preclinical trials have shown promise in reducing anxiety, and the few clinical trials studying Rhodiola rosea have supported a healthy heart and a healthy reproductive system.

This adaptogenic herb has caused controversy. In 2019, the U.S. Food and Drug Administration (FDA) issued warning letters to several supplement manufacturers who claimed, without high-quality evidence, that Rhodiola rosea treats Raynaud syndrome, depression, and cancer.

Other Natural Anxiety Prevention Strategies

Supplements are not the only way to treat anxiety. I also recommend lifestyle and dietary changes to my patients as natural ways to effectively treat and prevent anxiety.

Below are the best natural anxiety reduction treatments and evidence-based prevention strategies:

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What is the 3-3-3 rule for anxiety? The 3-3-3 rule helps you focus on sight, hearing, and touch by focusing on 3 things you can see, 3 things you can hear, then 3 parts of your body. This takes away focus from stressful, anxiety-inducing situations. The 3-3-3 rule may help those struggling with anxiety in real-time.

Caution: Seek medical advice from your healthcare provider before starting a new routine or making significant changes to your lifestyle and diet, especially if you have additional health conditions.

Understanding Anxiety

Anxiety is a set of symptoms, including stress responses, dread, unease, restlessness, panic attacks, and other related symptoms. 

Feelings of anxiety are not caused by a chemical imbalance in the brain. Nevertheless, the following chemicals are believed to contribute to anxiety:

Anxiety disorders are diagnosable medical conditions that have their own unique root causes and prevention strategies.

The most common types of anxiety disorders include:

Discuss with your doctor whether they might diagnose you with an anxiety disorder. A proper diagnosis is the first step towards targeted healing and management.

When to Seek Support

For many, these natural remedies will provide the anxiety relief they so desperately need, but there is no shame in seeking additional support from a healthcare provider.

Come to PrimeHealth integrative medicine clinic in Colorado. We respect our patients. We listen to our patients. We are honest with our patients. We utilize natural treatments, as well as prescription medications when necessary.


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